Oral antioxidant therapy for juvenile rats with kaolin-induced hydrocephalus
Identifieur interne : 000988 ( Main/Exploration ); précédent : 000987; suivant : 000989Oral antioxidant therapy for juvenile rats with kaolin-induced hydrocephalus
Auteurs : Domenico L. Di Curzio [Canada] ; Emily Turner-Brannen [Canada] ; Marc R. Del Bigio [Canada]Source :
- Fluids and Barriers of the CNS [ 2045-8118 ] ; 2014.
Abstract
Oxidative and nitrosylative changes have been shown to occur in conjunction with the hypoxic changes and cellular/axonal damage in hydrocephalic rodent brains. We hypothesized that antioxidant therapy would improve behavioral, neurophysiological, and/or neurobiochemical outcomes in juvenile rats following induction of hydrocephalus.
Three-week old rats received an injection of kaolin (aluminum silicate) into the cisterna magna. Magnetic resonance (MR) imaging was performed two weeks later to assess ventricle size and stratify rats to four treatment conditions. Rats were treated for two weeks daily with sham therapy of either oral canola oil or dextrose or experimental therapy of a low or high dose of an antioxidant mixture containing α-tocopherol, L-ascorbic acid, coenzyme Q10 (CoQ10), reduced glutathione, and reduced lipoic acid. Behavior was examined thrice weekly.
All hydrocephalic groups lagged in weight gain in comparison to non-hydrocephalic controls, all developed significant ventriculomegaly, and all exhibited white matter destruction. Canola oil with or without the antioxidant mixture normalized antioxidant capacity in brain tissue, and the dextrose-treated rats had the greatest ventricular enlargement during the treatment period. However, there were no significant differences between the four treatment groups of hydrocephalic rats for the various behavioral tasks. Glial fibrillary acidic protein and myelin basic protein quantitation showed no differences between the treatment groups or with control rats. There was increased lipid peroxidation in the hydrocephalic rats compared to controls but no differences between treatment groups.
The antioxidant cocktail showed no therapeutic benefits for juvenile rats with kaolin-induced hydrocephalus although canola oil might have mild benefit.
Url:
DOI: 10.1186/2045-8118-11-23
PubMed: 25324960
PubMed Central: 4199774
Affiliations:
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Di Curzio</name><affiliation wicri:level="1"><nlm:aff id="I1">Departments of Human Anatomy & Cell Science, 715 McDermot Avenue, Winnipeg, MB R3E 3P4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Departments of Human Anatomy & Cell Science, 715 McDermot Avenue, Winnipeg, MB R3E 3P4</wicri:regionArea><wicri:noRegion>MB R3E 3P4</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Manitoba Institute of Child Health, 715 McDermot Avenue, Winnipeg, MB R3E 3P4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Manitoba Institute of Child Health, 715 McDermot Avenue, Winnipeg, MB R3E 3P4</wicri:regionArea><wicri:noRegion>MB R3E 3P4</wicri:noRegion></affiliation></author><author><name sortKey="Turner Brannen, Emily" sort="Turner Brannen, Emily" uniqKey="Turner Brannen E" first="Emily" last="Turner-Brannen">Emily Turner-Brannen</name><affiliation wicri:level="1"><nlm:aff id="I2">Manitoba Institute of Child Health, 715 McDermot Avenue, Winnipeg, MB R3E 3P4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Manitoba Institute of Child Health, 715 McDermot Avenue, Winnipeg, MB R3E 3P4</wicri:regionArea><wicri:noRegion>MB R3E 3P4</wicri:noRegion></affiliation></author><author><name sortKey="Del Bigio, Marc R" sort="Del Bigio, Marc R" uniqKey="Del Bigio M" first="Marc R" last="Del Bigio">Marc R. 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Di Curzio</name><affiliation wicri:level="1"><nlm:aff id="I1">Departments of Human Anatomy & Cell Science, 715 McDermot Avenue, Winnipeg, MB R3E 3P4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Departments of Human Anatomy & Cell Science, 715 McDermot Avenue, Winnipeg, MB R3E 3P4</wicri:regionArea><wicri:noRegion>MB R3E 3P4</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Manitoba Institute of Child Health, 715 McDermot Avenue, Winnipeg, MB R3E 3P4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Manitoba Institute of Child Health, 715 McDermot Avenue, Winnipeg, MB R3E 3P4</wicri:regionArea><wicri:noRegion>MB R3E 3P4</wicri:noRegion></affiliation></author><author><name sortKey="Turner Brannen, Emily" sort="Turner Brannen, Emily" uniqKey="Turner Brannen E" first="Emily" last="Turner-Brannen">Emily Turner-Brannen</name><affiliation wicri:level="1"><nlm:aff id="I2">Manitoba Institute of Child Health, 715 McDermot Avenue, Winnipeg, MB R3E 3P4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Manitoba Institute of Child Health, 715 McDermot Avenue, Winnipeg, MB R3E 3P4</wicri:regionArea><wicri:noRegion>MB R3E 3P4</wicri:noRegion></affiliation></author><author><name sortKey="Del Bigio, Marc R" sort="Del Bigio, Marc R" uniqKey="Del Bigio M" first="Marc R" last="Del Bigio">Marc R. Del Bigio</name><affiliation wicri:level="1"><nlm:aff id="I2">Manitoba Institute of Child Health, 715 McDermot Avenue, Winnipeg, MB R3E 3P4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Manitoba Institute of Child Health, 715 McDermot Avenue, Winnipeg, MB R3E 3P4</wicri:regionArea><wicri:noRegion>MB R3E 3P4</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="I3">Department of Pathology, University of Manitoba, 727 McDermot Avenue, Winnipeg, R3E 3P5, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology, University of Manitoba, 727 McDermot Avenue, Winnipeg, R3E 3P5</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author></analytic><series><title level="j">Fluids and Barriers of the CNS</title><idno type="eISSN">2045-8118</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Oxidative and nitrosylative changes have been shown to occur in conjunction with the hypoxic changes and cellular/axonal damage in hydrocephalic rodent brains. We hypothesized that antioxidant therapy would improve behavioral, neurophysiological, and/or neurobiochemical outcomes in juvenile rats following induction of hydrocephalus.</p></sec><sec><title>Methods</title><p>Three-week old rats received an injection of kaolin (aluminum silicate) into the cisterna magna. Magnetic resonance (MR) imaging was performed two weeks later to assess ventricle size and stratify rats to four treatment conditions. Rats were treated for two weeks daily with sham therapy of either oral canola oil or dextrose or experimental therapy of a low or high dose of an antioxidant mixture containing α-tocopherol, L-ascorbic acid, coenzyme Q10 (CoQ10), reduced glutathione, and reduced lipoic acid. Behavior was examined thrice weekly.</p></sec><sec><title>Results</title><p>All hydrocephalic groups lagged in weight gain in comparison to non-hydrocephalic controls, all developed significant ventriculomegaly, and all exhibited white matter destruction. Canola oil with or without the antioxidant mixture normalized antioxidant capacity in brain tissue, and the dextrose-treated rats had the greatest ventricular enlargement during the treatment period. However, there were no significant differences between the four treatment groups of hydrocephalic rats for the various behavioral tasks. Glial fibrillary acidic protein and myelin basic protein quantitation showed no differences between the treatment groups or with control rats. There was increased lipid peroxidation in the hydrocephalic rats compared to controls but no differences between treatment groups.</p></sec><sec><title>Conclusion</title><p>The antioxidant cocktail showed no therapeutic benefits for juvenile rats with kaolin-induced hydrocephalus although canola oil might have mild benefit.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Del Bigio, M" uniqKey="Del Bigio M">M Del Bigio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcallister, J" uniqKey="Mcallister J">J McAllister</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Del Bigio, M" uniqKey="Del Bigio M">M Del Bigio</name></author><author><name sortKey="Khan, Oh" uniqKey="Khan O">OH Khan</name></author><author><name sortKey="Da Silva Lopes, L" uniqKey="Da Silva Lopes L">L da Silva Lopes</name></author><author><name sortKey="Packiasamy, Arj" uniqKey="Packiasamy 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Li</name></author><author><name sortKey="Klein, G" uniqKey="Klein G">G Klein</name></author><author><name sortKey="Sun, P" uniqKey="Sun P">P Sun</name></author><author><name sortKey="Buchan, Am" uniqKey="Buchan A">AM Buchan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sikorska, M" uniqKey="Sikorska M">M Sikorska</name></author><author><name sortKey="Borowy Borowski, H" uniqKey="Borowy Borowski H">H Borowy-Borowski</name></author><author><name sortKey="Zurakowski, B" uniqKey="Zurakowski B">B Zurakowski</name></author><author><name sortKey="Walker, Pr" uniqKey="Walker P">PR Walker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanchez Moreno, C" uniqKey="Sanchez Moreno C">C Sánchez-Moreno</name></author><author><name sortKey="Dorfman, Se" uniqKey="Dorfman S">SE Dorfman</name></author><author><name sortKey="Lichtenstein, Ah" uniqKey="Lichtenstein A">AH Lichtenstein</name></author><author><name sortKey="Martin, A" uniqKey="Martin A">A Martín</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuwahara, H" uniqKey="Kuwahara H">H Kuwahara</name></author><author><name sortKey="Kanazawa, A" uniqKey="Kanazawa A">A Kanazawa</name></author><author><name sortKey="Wakamatsu, D" uniqKey="Wakamatsu D">D Wakamatsu</name></author><author><name sortKey="Morimura, S" uniqKey="Morimura S">S Morimura</name></author><author><name sortKey="Kida, K" uniqKey="Kida K">K Kida</name></author><author><name sortKey="Akaike, T" uniqKey="Akaike T">T Akaike</name></author><author><name sortKey="Maeda, H" uniqKey="Maeda H">H Maeda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Torreilles, F" uniqKey="Torreilles F">F Torreilles</name></author><author><name sortKey="Salman Tabcheh, S" uniqKey="Salman Tabcheh S">S Salman-Tabcheh</name></author><author><name sortKey="Guerin, M" uniqKey="Guerin M">M Guerin</name></author><author><name sortKey="Torreilles, J" uniqKey="Torreilles J">J Torreilles</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Szabo, C" uniqKey="Szabo C">C Szabo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Quijano, C" uniqKey="Quijano C">C Quijano</name></author><author><name sortKey="Romero, N" uniqKey="Romero N">N Romero</name></author><author><name sortKey="Radi, R" uniqKey="Radi R">R Radi</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li></country><region><li>Manitoba</li></region><settlement><li>Winnipeg</li></settlement><orgName><li>Université du Manitoba</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Di Curzio, Domenico L" sort="Di Curzio, Domenico L" uniqKey="Di Curzio D" first="Domenico L" last="Di Curzio">Domenico L. Di Curzio</name></noRegion><name sortKey="Del Bigio, Marc R" sort="Del Bigio, Marc R" uniqKey="Del Bigio M" first="Marc R" last="Del Bigio">Marc R. Del Bigio</name><name sortKey="Del Bigio, Marc R" sort="Del Bigio, Marc R" uniqKey="Del Bigio M" first="Marc R" last="Del Bigio">Marc R. Del Bigio</name><name sortKey="Di Curzio, Domenico L" sort="Di Curzio, Domenico L" uniqKey="Di Curzio D" first="Domenico L" last="Di Curzio">Domenico L. Di Curzio</name><name sortKey="Turner Brannen, Emily" sort="Turner Brannen, Emily" uniqKey="Turner Brannen E" first="Emily" last="Turner-Brannen">Emily Turner-Brannen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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